Document Detail


Divergent estrogen receptor-positive and -negative breast cancer trends and etiologic heterogeneity in Denmark.
MedLine Citation:
PMID:  23616071     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term breast cancer trends in incidence in the United States (US) show rising estrogen receptor (ER)-positive rates and falling ER-negative rates. We hypothesized that these divergent trends reflect etiologic heterogeneity and that comparable trends should be observed in other countries with similar risk factor profiles. Therefore, we analyzed invasive female breast cancers in Denmark, a country with similar risk factors as the US. We summarized the overall trend in age-standardized rates with the estimated annual percentage change (EAPC) statistic (1993-2010) and used age-period-cohort models to estimate age-specific EAPCs, cohort rate ratios and projections for future time periods (2011-2018). In Denmark, the overall rate of ER-positive cancers rose between 1993 and 2010 by 3.0% per year (95% CI: 2.8-3.3% per year), whereas the overall rate of ER-negative cancers fell by 2.1% per year (95% CI: -2.5 to -1.6% per year). The ER-positive rate increased fastest among postmenopausal women and the ER-negative rate decreased fastest among premenopausal women, reflecting that cohorts born after 1944 were at relatively higher risk of ER-positive tumors and lower risk of ER-negative tumors. If current trends continue, ER-positive cancers will increase at least 13% by 2018 in Denmark, ER-negative cancers will fall 15% by 2018, and breast cancer overall will increase at least 7% by 2018. Divergent ER-specific trends are consistent with distinct etiologic pathways. If trends in known risk factors are responsible, the Danish and US experience may foreshadow a common pattern worldwide.
Authors:
William F Anderson; Philip S Rosenberg; Lucia Petito; Hormuzd A Katki; Bent Ejlertsen; Marianne Ewertz; Birgitte B Rasmussen; Maj-Britt Jensen; Niels Kroman
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-06-13
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  133     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-08-20     Completed Date:  2013-10-31     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2201-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 UICC.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Breast Neoplasms / epidemiology*,  etiology*,  metabolism,  pathology
Denmark / epidemiology
Female
Follow-Up Studies
Humans
Incidence
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Prognosis
Receptors, Estrogen / metabolism*
Risk Factors
Time Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
Z01 CP010183-06/CP/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Estrogen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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