Document Detail

Divergent effects of rosiglitazone on protein-mediated fatty acid uptake in adipose and in muscle tissues of Zucker rats.
MedLine Citation:
PMID:  15772429     Owner:  NLM     Status:  MEDLINE    
Thiazolidinediones (TZDs) increase tissue insulin sensitivity in diabetes. Here, we hypothesize that, in adipose tissue, skeletal muscle, and heart, alterations in protein-mediated FA uptake are involved in the effect of TZDs. As a model, we used obese Zucker rats, orally treated for 16 days with 5 mg rosiglitazone (Rgz)/kg body mass/day. In adipose tissue from Rgz-treated rats, FA uptake capacity increased by 2.0-fold, coinciding with increased total contents of fatty acid translocase (FAT/CD36; 2.3-fold) and fatty acid transport protein 1 (1.7-fold) but not of plasmalemmal fatty acid binding protein, whereas only the plasmalemmal content of FAT/CD36 was changed (increase of 1.7-fold). The increase in FA uptake capacity of adipose tissue was associated with a decline in plasma FA and triacylglycerols (TAGs), suggesting that Rgz treatment enhanced plasma FA extraction by adipocytes. In obese hearts, Rgz treatment had no effect on the FA transport system, yet the total TAG content decreased, suggesting enhanced insulin sensitivity. Also, in skeletal muscle, the FA transport system was not changed. However, the TAG content remained unaltered in skeletal muscle, which coincided with increased cytoplasmic adipose-type FABP content, suggesting that increased extramyocellular TAGs mask the decline of intracellular TAG in muscle. In conclusion, our study implicates FAT/CD36 in the mechanism by which Rgz increases tissue insulin sensitivity.
S L M Coort; W A Coumans; A Bonen; G J van der Vusse; J F C Glatz; J J F P Luiken
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-03-16
Journal Detail:
Title:  Journal of lipid research     Volume:  46     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-13     Completed Date:  2005-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1295-302     Citation Subset:  IM    
Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
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MeSH Terms
Adipocytes / metabolism
Adipose Tissue / metabolism*
Antigens, CD36 / biosynthesis
Cell Membrane / metabolism
Fatty Acid Transport Proteins
Fatty Acids / metabolism*
Hypoglycemic Agents / pharmacology*
Membrane Transport Proteins / metabolism
Muscle, Skeletal / metabolism
Muscles / metabolism*
Obesity / metabolism
Palmitic Acid / metabolism
Rats, Zucker
Thiazolidinediones / pharmacology*
Triglycerides / metabolism
Reg. No./Substance:
0/Antigens, CD36; 0/Fatty Acid Transport Proteins; 0/Fatty Acids; 0/Hypoglycemic Agents; 0/Membrane Transport Proteins; 0/Thiazolidinediones; 0/Triglycerides; 122320-73-4/rosiglitazone; 57-10-3/Palmitic Acid

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