Document Detail

Divergent effects of ethinylestradiol?drospirenone and flutamide?metformin on follistatin in adolescents and women with hyperinsulinemic androgen excess.
MedLine Citation:
PMID:  20528210     Owner:  NLM     Status:  In-Data-Review    
Randomized studies have disclosed that ethinylestradiol?drospirenone and flutamide?metformin have divergent effects on the body adiposity and adipokines of adolescents and young women with hyperinsulinemic androgen excess. We have now tested in 41 patients from those original studies whether the divergent effects on body adiposity could be mediated by divergent levels of follistatin, an adipokine that promotes subcutaneous adipogenesis. Circulating follistatin was measured, at study start and after 9 months, with an enzyme-linked immunosorbent assay. Treatment with ethinylestradiol?drospirenone was accompanied by a more adipose body composition and by a nearly 4-fold rise of follistatinemia (P?<?0.0001). In contrast, treatment with low-dose flutamide?metformin did not increase body adiposity and did not alter follistatinemia detectably. Finally, combined treatment with ethinylestradiol?drospirenone and flutamide?metformin was accompanied by an intermediate (2- to 3-fold) rise of follistatinemia (P?<?0.005). In conclusion, the principle that ethinylestradiol?drospirenone and flutamide?metformin exert diverging effects on adipokines is herewith broadened to include circulating follistatin. Hyperfollistatinemia may be among the mechanisms whereby oral contraceptives aggravate the body adiposity of adolescents and young women with hyperinsulinemic androgen excess.
Lourdes Ib Ez; Marta D Az; Abel L Pez-Bermejo; Francis de Zegher
Publication Detail:
Type:  Journal Article     Date:  2010-06-08
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  27     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-8     Citation Subset:  IM    
Endocrinology Unit, Hospital Sant Joan de D?u, University of Barcelona, 08950 Esplugues, Barcelona, Spain.
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