Document Detail

Divergent effects of eicosapentaenoic and docosahexaenoic acid ethyl esters, and fish oil on hepatic fatty acid oxidation in the rat.
MedLine Citation:
PMID:  14642774     Owner:  NLM     Status:  MEDLINE    
The physiological activity of fish oil, and ethyl esters of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) affecting hepatic fatty acid oxidation was compared in rats. Five groups of rats were fed various experimental diets for 15 days. A group fed a diet containing 9.4% palm oil almost devoid of n-3 fatty acids served as a control. The test diets contained 4% n-3 fatty acids mainly as EPA and DHA in the form of triacylglycerol (9.4% fish oil) or ethyl esters (diets containing 4% EPA ethyl ester, 4% DHA ethyl ester, and 1% EPA plus 3% DHA ethyl esters). The lipid content of diets containing EPA and DHA ethyl esters was adjusted to 9.4% by adding palm oil. The fish oil diet and ethyl ester diets, compared to the control diet containing 9.4% palm oil, increased activity and mRNA levels of hepatic mitochondrial and peroxisomal fatty acid oxidation enzymes, though not 3-hydroxyacyl-CoA dehydrogenase activity. The extent of the increase was, however, much greater with the fish oil than with EPA and DHA ethyl esters. EPA and DHA ethyl esters, compared to the control diet, increased 3-hydroxyacyl-CoA dehydrogenase activity, but fish oil strongly reduced it. It is apparent that EPA and DHA in the form of ethyl esters cannot mimic the physiological activity of fish oil at least in affecting hepatic fatty acid oxidation in rat.
Dang Diem Hong; Yoko Takahashi; Masay Kushiro; Takashi Ide
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1635     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Division of Physiology and Nutrition, Laboratory of Nutritional Biochemistry, National Food Research Institute, 2-1-12 Kannondai, Tsukuba 305-8642, Japan.
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MeSH Terms
Acyl-CoA Oxidase / metabolism
Coenzyme A / metabolism
Dietary Fats / pharmacology
Eicosapentaenoic Acid / analogs & derivatives*,  pharmacology*
Fatty Acids, Nonesterified / metabolism*
Fatty Acids, Unsaturated / pharmacology*
Fish Oils / pharmacology*
Lipid Metabolism
Liver / drug effects,  metabolism*
Mitochondria, Liver / drug effects,  enzymology
Peroxisomes / drug effects,  enzymology
Phospholipids / metabolism
Plant Oils
Triglycerides / metabolism
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Phospholipids; 0/Plant Oils; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25448-00-4/docosapentaenoic acid; 73310-10-8/eicosapentaenoic acid ethyl ester; 8002-75-3/palm oil; 85-61-0/Coenzyme A; EC Oxidase

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