| Divergent effects of angiotensin-converting enzyme inhibition on blood pressure and endothelial function in obese humans. | |
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MedLine Citation:
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PMID: 16784179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelial dysfunction is a pivotal early event in the development of atherosclerosis and a characteristic feature of obesity. This study was designed to investigate the effect of angiotensin-converting enzyme (ACE) inhibition on endothelial function in people who were obese but otherwise healthy. We performed a double-blind, randomised, placebo-controlled study examining the effect of the ACE inhibitor perindopril (4 mg per day) on flow-mediated vasodilatation (FMD) of the brachial artery, arterial blood pressure, glucose homeostasis and inflammatory cytokines. Eighteen obese subjects (all body mass index > 30 kg/m2) were randomised to receive perindopril or placebo for four weeks. Perindopril led to a fall in systolic blood pressure from 131 (standard error of mean [SEM] 3) to 117(5) mmHg and diastolic blood pressure from 74(4) mmHg to 68(4) mmHg, both p<0.001. Despite this fall in blood pressure, ACE inhibition had no effect on FMD, 8.2 (1.2)% versus 8.3 (1.5)%, p=0.9. ACE inhibition had no effect on insulin, lipids or circulating cytokines. In healthy obese humans, despite a significant reduction in blood pressure, ACE inhibition had no effect on FMD. |
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Authors:
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Ian L Williams; Philip J Chowienczyk; Stephen B Wheatcroft; Ameet G Patel; Roy A Sherwood; Ajay M Shah; Mark T Kearney |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease Volume: 3 ISSN: 1479-1641 ISO Abbreviation: - Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-06-20 Completed Date: 2006-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101234011 Medline TA: Diab Vasc Dis Res Country: England |
Other Details:
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Languages: eng Pagination: 34-8 Citation Subset: IM |
Affiliation:
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GKT School of Medicine, King's College, London, SE5 9PJ, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin-Converting Enzyme Inhibitors / pharmacology* Blood Pressure / drug effects* Brachial Artery / drug effects Endothelium, Vascular / drug effects* Female Humans Lipid Metabolism / drug effects Male Middle Aged Obesity / metabolism*, physiopathology Perindopril / pharmacology* Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 82834-16-0/Perindopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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