Document Detail

Divergent effects of angiotensin-converting enzyme inhibition on blood pressure and endothelial function in obese humans.
MedLine Citation:
PMID:  16784179     Owner:  NLM     Status:  MEDLINE    
Endothelial dysfunction is a pivotal early event in the development of atherosclerosis and a characteristic feature of obesity. This study was designed to investigate the effect of angiotensin-converting enzyme (ACE) inhibition on endothelial function in people who were obese but otherwise healthy. We performed a double-blind, randomised, placebo-controlled study examining the effect of the ACE inhibitor perindopril (4 mg per day) on flow-mediated vasodilatation (FMD) of the brachial artery, arterial blood pressure, glucose homeostasis and inflammatory cytokines. Eighteen obese subjects (all body mass index > 30 kg/m2) were randomised to receive perindopril or placebo for four weeks. Perindopril led to a fall in systolic blood pressure from 131 (standard error of mean [SEM] 3) to 117(5) mmHg and diastolic blood pressure from 74(4) mmHg to 68(4) mmHg, both p<0.001. Despite this fall in blood pressure, ACE inhibition had no effect on FMD, 8.2 (1.2)% versus 8.3 (1.5)%, p=0.9. ACE inhibition had no effect on insulin, lipids or circulating cytokines. In healthy obese humans, despite a significant reduction in blood pressure, ACE inhibition had no effect on FMD.
Ian L Williams; Philip J Chowienczyk; Stephen B Wheatcroft; Ameet G Patel; Roy A Sherwood; Ajay M Shah; Mark T Kearney
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease     Volume:  3     ISSN:  1479-1641     ISO Abbreviation:  -     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-20     Completed Date:  2006-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101234011     Medline TA:  Diab Vasc Dis Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
GKT School of Medicine, King's College, London, SE5 9PJ, UK.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Blood Pressure / drug effects*
Brachial Artery / drug effects
Endothelium, Vascular / drug effects*
Lipid Metabolism / drug effects
Middle Aged
Obesity / metabolism*,  physiopathology
Perindopril / pharmacology*
Vasodilation / drug effects
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 82834-16-0/Perindopril

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