Document Detail

Divergent blood pressure responses during short-term sodium restriction in hypertension.
MedLine Citation:
PMID:  6987029     Owner:  NLM     Status:  MEDLINE    
In untreated patients with essential hypertension, daily sodium intake was reduced from 197 to 70 mEq/day in 82 outpatients and from 124 to 14 mEq/day in 25 patients in a metabolic ward. During the 10 days of sodium restriction 17% of the outpatients and 40% of the inpatients had mean blood pressure decreases of at least 10 mm Hg, but in 17% of the outpatients and 28% of the inpatients mean pressure rose at least 5 mm Hg. Most blood pressure decreases occurred in the group with high-renin hypertension. Our short-term experience suggests that dietary salt deprivation may not be effective treatment for all patients with hypertension and may even be counterproductive in some.
D L Longworth; J I Drayer; M A Weber; J H Laragh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  27     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-05-23     Completed Date:  1980-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  544-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure*
Diet, Sodium-Restricted*
Hypertension / diet therapy*,  physiopathology
Middle Aged
Renin / blood
Sodium / urine
Time Factors
Reg. No./Substance:
7440-23-5/Sodium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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