Document Detail


Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework.
MedLine Citation:
PMID:  24512549     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of kidney pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year bioassay. Diuron is registered for both occupational and residential uses and is used worldwide for more than 30 different crops. The proposed rat urothelial mode of action (MOA) for this herbicide consists of metabolic activation to metabolites that are excreted and concentrated in the urine, leading to cytotoxicity, urothelial cell necrosis and exfoliation, regenerative hyperplasia, and eventually tumors. We show evidence for this MOA for diuron using the International Programme on Chemical Safety (IPCS) conceptual framework for evaluating an MOA for chemical carcinogens, and the United States Environmental Protection Agency (USEPA) and IPCS framework for assessing human relevance.
Authors:
Mitscheli Sanches Da Rocha; Lora L Arnold; Maria Luiza Cotrim Sartor De Oliveira; Shadia M Ihlaseh Catalano; Ana Paula Ferragut Cardoso; Merielen G N Pontes; Bianca Ferrucio; Puttappa R Dodmane; Samuel M Cohen; João Lauro V De Camargo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-11
Journal Detail:
Title:  Critical reviews in toxicology     Volume:  -     ISSN:  1547-6898     ISO Abbreviation:  Crit. Rev. Toxicol.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914275     Medline TA:  Crit Rev Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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