Document Detail

Diurnal variation of urinary histamine and 1-methylhistamine excretion in healthy children.
MedLine Citation:
PMID:  1285571     Owner:  NLM     Status:  MEDLINE    
In order to establish a noninvasive method of monitoring immediate hypersensitivity reactions in children, we studied the diurnal variation of urinary histamine and 1-methylhistamine excretion and the influence of food intake in a group of 14 healthy nonatopic children (aged 2-16 years). Histamine and 1-methylhistamine in spontaneous urine samples were determined by radioimmunoassay. Mean variation of 2-h intervals was much higher for urinary histamine than for 1-methylhistamine (45% of base-line level versus 24%). There was no circadian rhythm or influence of food intake. The short half-life of histamine released into blood circulation may be the main reason for the higher variation of histamine excretion. In children, urinary 1-methylhistamine is less influenced by diurnal variation and is therefore more suited to monitor immediate hypersensitivity reactions than urinary histamine itself.
S Schulze; B Niggemann; A N Savaser; U Wahn
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  47     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-03-10     Completed Date:  1993-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  644-9     Citation Subset:  IM    
University Children's Hospital (KAVH), Berlin, Germany.
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MeSH Terms
Child, Preschool
Circadian Rhythm / physiology*
Creatinine / urine
Histamine / urine*
Hypersensitivity, Immediate / immunology,  urine
Methylhistamines / urine*
Reference Values
Reg. No./Substance:
0/Methylhistamines; 51-45-6/Histamine; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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