| Diurnal variation of urinary histamine and 1-methylhistamine excretion in healthy children. | |
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MedLine Citation:
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PMID: 1285571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to establish a noninvasive method of monitoring immediate hypersensitivity reactions in children, we studied the diurnal variation of urinary histamine and 1-methylhistamine excretion and the influence of food intake in a group of 14 healthy nonatopic children (aged 2-16 years). Histamine and 1-methylhistamine in spontaneous urine samples were determined by radioimmunoassay. Mean variation of 2-h intervals was much higher for urinary histamine than for 1-methylhistamine (45% of base-line level versus 24%). There was no circadian rhythm or influence of food intake. The short half-life of histamine released into blood circulation may be the main reason for the higher variation of histamine excretion. In children, urinary 1-methylhistamine is less influenced by diurnal variation and is therefore more suited to monitor immediate hypersensitivity reactions than urinary histamine itself. |
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Authors:
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S Schulze; B Niggemann; A N Savaser; U Wahn |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Allergy Volume: 47 ISSN: 0105-4538 ISO Abbreviation: Allergy Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-03-10 Completed Date: 1993-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: DENMARK |
Other Details:
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Languages: eng Pagination: 644-9 Citation Subset: IM |
Affiliation:
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University Children's Hospital (KAVH), Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Circadian Rhythm / physiology* Creatinine / urine Eating Female Histamine / urine* Humans Hypersensitivity, Immediate / immunology, urine Male Methylhistamines / urine* Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Methylhistamines; 51-45-6/Histamine; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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