Document Detail

Diurnal variation and increase of disaccharidase activity in diabetic rats.
MedLine Citation:
PMID:  1453237     Owner:  NLM     Status:  MEDLINE    
The small intestinal disaccharidase activity and its daily variation in the diabetic rat have not been well described. Therefore, the small intestinal disaccharidase (maltase, lactase and sucrase) activity and its daily profile were studied in streptozotocin-induced diabetic rats under physiological conditions. In diabetic rats, a similar pattern of diurnal variation of disaccharidase activity to control rats was observed, while the relationships between daily change of disaccharidase activity and that of food consumption suggested that there was a different mechanism of diurnal variation in diabetic rats. On the other hand, a significant increase of mean 24-h lactase and sucrase activities was noted in diabetic rats, while that of maltase was not significant. Using the in vitro incubation method, a significant correlation between glucose concentration and lactase or sucrase activity but not maltase activity was observed. However, insulin showed no effect on disaccharidase activity. Thus we clarified the presence of a diurnal variation of disaccharidase activity and an increase in its activity in diabetic rats. This change was suggested to be derived from high plasma glucose level.
K Nashiro; K Murakami; G Mimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  38     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1993-01-06     Completed Date:  1993-01-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  265-76     Citation Subset:  IM    
Second Department of Internal Medicine, School of Medicine, University of the Ryukyus, Okinawa, Japan.
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MeSH Terms
Blood Glucose / analysis
Circadian Rhythm*
Diabetes Mellitus, Experimental / enzymology*
Disaccharidases / analysis*
Glucose / pharmacology
Insulin / pharmacology
Intestinal Mucosa / enzymology
Rats, Wistar
Sucrase / analysis
alpha-Glucosidases / analysis
beta-Galactosidase / analysis
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose; EC 3.2.1.-/Disaccharidases; EC; EC; EC; EC

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