Document Detail

Diurnal variation in norepinephrine-stimulated release of pineal serotonin in vitro.
MedLine Citation:
PMID:  2754432     Owner:  NLM     Status:  MEDLINE    
Adult, male rats were maintained under 12L:12D with lights on at 06.00h. Their pineal glands were incubated at 37 degrees C in the presence or absence of 10(-4)M norepinephrine (NE). 5-HT and various metabolites were quantitated in post-incubation media and pineal glands by high performance liquid chromatography coupled with electrochemical detection. No differences were observed in the quantities of 5-HT released by pineal glands in four hour incubations starting at either 06.00, 13.00 or 18.00 h; however, a highly significant decrease below these levels was observed at 01.00h. NE significantly stimulated 5-HT release at 13.00 and 18.00 h, but was ineffective at 01.00 and 06.00h. These results confirm recently reported stimulatory effects of NE on the release of 5-HT into pineal gland incubation medium and further suggest a diurnal rhythm of pineal gland sensitivity to NE in vitro with maximum stimulation of 5-HT release at midphotophase.
B Benson; W D Reynolds; D M Burns; C A Leadem
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neural transmission. General section     Volume:  78     ISSN:  -     ISO Abbreviation:  J. Neural Transm. Gen. Sect.     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-07     Completed Date:  1989-09-07     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9002201     Medline TA:  J Neural Transm Gen Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  89-101     Citation Subset:  IM    
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MeSH Terms
Circadian Rhythm*
Norepinephrine / pharmacology*
Pineal Gland / drug effects*,  metabolism
Rats, Inbred Strains
Serotonin / metabolism*
Tryptophan / pharmacology
Grant Support
Reg. No./Substance:
333DO1RDJY/Serotonin; 8DUH1N11BX/Tryptophan; X4W3ENH1CV/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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