| Diurnal variation and effect of insulin on circulating high molecular weight (HMW) adiponectin and NF-κB activity in human endothelial cells. | |
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MedLine Citation:
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PMID: 21067753 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To study the diurnal variation and the effect of insulin on adiponectin multimers and nuclear factor-kappaB (NF-κB) activity in human endothelial cells. METHODS AND RESULTS: We utilized a prolonged insulin-glucose infusion in six healthy human subjects. HMW and total adiponectin levels were higher in the morning and lower at night; NF-κB activities in serum treated human microvascular endothelial cells (HMEC-1) cells were lower in the morning and higher at night. Hyperinsulinemic induction significantly decreased HMW and total adiponectin levels but increased NF-κB activity in serum treated HMEC-1 cells (P<0.05, P<0.01). There were no significant changes to MMW and LMW adiponectin levels (P>0.05). CONCLUSION: Circadian rhythm of HMW adiponectin and NF-κB activity are altered by hyperinsulinemia providing novel insights adiponectin and NF-κB biology, which may be pertinent to insulin resistant states, e.g. obesity and type 2 diabetes mellitus. |
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Authors:
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Bee K Tan; Raghu Adya; Krzysztof C Lewandowski; J Paul O'Hare; Harpal S Randeva |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-19 |
Journal Detail:
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Title: Atherosclerosis Volume: 214 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 174-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. B.K.Tan.1@warwick.ac.uk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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