| Diurnal variation and dispersion in QT interval in cirrhosis: relation to haemodynamic changes. | |
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MedLine Citation:
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PMID: 17459513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: A long QT(C) interval has been described in a substantial fraction of patients with cirrhosis, but information on QT variation and dispersion is sparse. The aim was to determine QT variation with time and QT dispersion (QT(disp)). METHODS: The study population comprised 23 patients with cirrhosis, undergoing a haemodynamic investigation. 24-h 12 lead Holter monitoring provided information on QT and heart rate variability. RESULTS: Mean QT(C) was above upper normal limit (440 ms(1/2)) in eleven patients (47%) and significantly higher than in controls (441 vs 400 ms(1/2), p<0.01). The minimum value of QT(C) (but not the maximum value) showed a significant diurnal variation both in cirrhosis and controls. QT(disp) in cirrhosis and controls was similar (33 vs 36 ms, ns), but related to indicators of liver dysfunction, central circulation time, and arterial blood pressure (r=0.44-0.58, p=0.03-0.001). No diurnal variation of QT(disp) was found in cirrhosis. Heart rate variability was reduced with a significant relation to central hypovolaemia (r=0.55, p=0.01). CONCLUSIONS: Twenty-four hours QT(C) is prolonged in a substantial fraction of patients with cirrhosis, but with normal diurnal variation. The combination of long QT(C) and normal QT(disp) suggests delayed myocyte repolarisation on the cellular level, rather than temporal and spatial heterogeneity in the myocardial wall. |
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Authors:
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Stig Hansen; Søren Møller; Flemming Bendtsen; Gorm Jensen; Jens H Henriksen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-05 |
Journal Detail:
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Title: Journal of hepatology Volume: 47 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-06 Completed Date: 2007-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 373-80 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology, 239, H:S Hvidovre Hospital, University of Copenhagen, DK-2650 Hvidovre, Denmark. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Circulation Blood Pressure Blood Volume Circadian Rhythm* Electrocardiography Electrophysiology Female Heart / physiopathology Heart Rate* Humans Hypovolemia / etiology, physiopathology Liver / physiopathology Liver Cirrhosis / complications*, physiopathology Long QT Syndrome / diagnosis, etiology*, physiopathology* Male Middle Aged Myocardium / pathology Time Factors |
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