| Diurnal variation of cadmium-induced mortality in mice. | |
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MedLine Citation:
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PMID: 22293423 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Circadian timing largely modifies efficacy of many medicinal drugs. This viewpoint has been applied in the clinical medicine, known as chronotherapy. We think this viewpoint should also be introduced into toxicology as "chronotoxicology", however, information about the diurnal variation in toxicant sensitivity is still very scarce. We present here a clear and reproducible diurnal variation of cadmium (Cd)-induced mortality in mice. Male ICR mice kept under standard condition (12 hr light/dark cycle, lights on at 08:00) were injected with CdCl(2) (7.2 mg/kg, one shot) intraperitoneally at different time points in the day (zeitgeber time (ZT) 0, 4, 8, 12, 16 or 20). Survival number was determined at 14 days after injection. Interestingly, mice were sensitive to Cd acute toxicity at ZT8, while tolerant at mid-dark to early-light phase (ZT16, ZT20 and ZT0). Hepatic GSH level showed small daily fluctuation, lowest at ZT8 and highest at ZT20, and this fluctuation was similar to the diurnal variation of Cd sensitivity. In contrast, hepatic metallothionein (MT) level was not significant in these time points, although their level also showed small daily fluctuation. Our results indicated that Cd-induced mortality had clear diurnal variation, and suggested that the hepatic GSH level was one of the important factors for determination of this Cd-induced diurnal mortality. |
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Authors:
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Nobuhiko Miura; Yukie Yanagiba; Katsumi Ohtani; Masaharu Mita; Masako Togawa; Tatsuya Hasegawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of toxicological sciences Volume: 37 ISSN: 1880-3989 ISO Abbreviation: J Toxicol Sci Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805798 Medline TA: J Toxicol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 191-6 Citation Subset: IM |
Affiliation:
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Division of Health Effects Research, Japan National Institute of Occupational Safety and Health. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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