Document Detail

Diurnal variation of blood pressure in patients with catecholamine-producing tumors.
MedLine Citation:
PMID:  7917145     Owner:  NLM     Status:  MEDLINE    
To investigate the role of plasma catecholamines in diurnal blood pressure variation, invasive 24-h ambulatory blood pressure recordings (Oxford technique) were performed on 10 untreated patients; all had increased plasma concentrations of norepinephrine (mean 27.3; range 2.50 to 134.6 nmol/L) or epinephrine (mean 13.5; range 0.13 to 96.6 nmol/L) either attributable to a pheochromocytoma (n = 7) or a paraganglioma (n = 3). The nocturnal change in blood pressure was calculated as the percentage difference of blood pressure between night (midnight to 6 AM) and day (8 AM to 10 PM). The group average nocturnal change in blood pressure was 12.4%, ranging from a 32.0% decrease to a 2.8% increase, whereas the average nocturnal fall in heart rate was 18.6%, ranging from 2.2% to 33.4%. Although the nocturnal change in blood pressure was not significantly correlated with plasma values of norepinephrine (r = 0.60) or total catecholamines (r = 0.54), no nocturnal decrease in blood pressure occurred in the two patients with a plasma norepinephrine level of > 55 nmol/L. Recordings of three patients, all with a pheochromocytoma showed several paroxysms of blood pressure elevations, which lasted 18 to 47 min and had an amplitude of 32 to 94 mm Hg. In two cases these elevations had a true cyclic character. Our findings indicate that patients with a catecholamine-producing tumor may exhibit a normal diurnal blood pressure variation with a decrease in blood pressure during the night, suggesting that factors responsible for this diurnal variation remain operative in this condition.(ABSTRACT TRUNCATED AT 250 WORDS)
R G van Eps; A H van den Meiracker; F Boomsma; A J Man in't Veld; M A Schalekamp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  7     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-08     Completed Date:  1994-11-08     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  492-7     Citation Subset:  IM    
Department of Internal Medicine I, University Hospital Dijkzigt, Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm
Epinephrine / blood*
Heart Rate
Middle Aged
Norepinephrine / blood*
Paraganglioma / blood,  physiopathology*
Pheochromocytoma / blood,  physiopathology*
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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