Document Detail

Diurnal variation of arterial stiffness and subendocardial perfusion noninvasively assessed using applanation tonometry in healthy young men.
MedLine Citation:
PMID:  15989114     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Arterial stiffness is at least partially controlled by vascular tone. Vascular tone and underlying physiological processes, e.g. sympathetic activity, have been shown to follow diurnal variations. METHODS: This study investigated whether arterial stiffness and perfusion of subendocardial myocardium relative to cardiac workload show diurnal variations under physiological conditions. The aortic augmentation index (AIx) and subendocardial viability ratio (SEVR) were measured noninvasively in 26 healthy young men (27.6 +/- 3.4 years) using applanation tonometry at three different times (8:00, 12:00, 17:00) during one day. RESULTS: Mean AIx was significantly higher and mean SEVR significantly lower at 8:00 than at the later times. No significant differences were found between mean AIx and mean SEVR at 12:00 and at 17:00. CONCLUSIONS: The observed diurnal variations of AIx and SEVR will be of value when applanation tonometry is used in human research. In order to arrive at comparable data in longitudinal investigations, measurements should be made at similar times during the course of a day. In addition, our observation should assist in studies in which novel pharmacological compounds with activity on the vasculature are investigated.
Gerd Bodlaj; Jörg Berg; Georg Biesenbach
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  117     ISSN:  0043-5325     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-07-01     Completed Date:  2005-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  348-52     Citation Subset:  IM    
Second Department of Medicine, General Hospital Linz, Linz, Austria.
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MeSH Terms
Aorta / physiology*
Blood Flow Velocity / physiology
Blood Pressure / physiology*
Blood Pressure Determination / methods*
Circadian Rhythm / physiology*
Coronary Circulation / physiology*
Endocardium / physiology*
Manometry / methods*
Radial Artery / physiology*
Stress, Mechanical

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