| Diurnal rhythm of core body temperature is phase advanced in a rodent model of depression. | |
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MedLine Citation:
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PMID: 2049491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the diurnal rhythm of core body temperature in a strain of rats with an upregulated central muscarinic receptor system. The Flinders-Sensitive Line (FSL) was derived by selectively breeding rats for sensitivity to cholinergic agonists. When compared to control rats, the FSL rats showed a remarkably strong phase advance of the acrophase in body temperature during a standard light-dark schedule. Some patients with some types of depression also show phase advances in a number of circadian rhythms, including temperature. Our finding of a phase advance in a rodent model with a known upregulated muscarinic receptor system is compatible with both the phase advance and the muscarinic overdrive theories of depression. These findings also further validate the usefulness of the FSL rats in the study of depression. |
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Authors:
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P J Shiromani; H Klemfuss; S Lucero; D H Overstreet |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biological psychiatry Volume: 29 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-07-25 Completed Date: 1991-07-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 923-30 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, San Diego VA Medical Center, CA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature* Brain / physiopathology Circadian Rhythm* Depressive Disorder / diagnosis, physiopathology* Models, Biological Rats Receptors, Muscarinic / physiology Sleep, REM / physiology |
| Grant Support | |
ID/Acronym/Agency:
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NS25212/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Muscarinic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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