| Diurnal and monthly intra-individual variability of the concentration of lipids, lipoproteins and apoproteins. | |
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MedLine Citation:
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PMID: 2247768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diurnal and monthly variability of the serum concentration of lipids, lipoproteins and apoproteins were examined in 11 healthy subjects aged 32-63 (mean 46) years. For diurnal measurements, blood samples were drawn at 0800, 1200, 1500, 1800, and 2100 hours. The variability over 1 month was assessed from four analyses taken weekly at 0800 hours after at least 8 h fast. The analytical variability expressed as mean coefficient of variation (CV) ranged from 0.95% for cholesterol to 7.6% for apoprotein B. The mean CVs for diurnal biological variability were 2.4% for cholesterol, 3.5% for HDL-cholesterol, 5.1% for LDL-cholesterol, 29.5% for triglycerides, 6.5% for apoprotein A and 6.5% for apoprotein B. The respective biological CVs for monthly variability were 4.2%, 4.1%, 5.2%, 20.7%, 9.4% and 9.7%. A repeated-measures ANOVA revealed a significant increase of triglycerides (p less than 0.01) and decrease of LDL-cholesterol (p less than 0.01) during the day. Within 1 month, apoprotein A tended to rise (0.05 less than p less than 0.10). Although the best reproducibility was found for cholesterol, the results obtained indicate that six tests have to be taken before and after intervention by drug or diet to detect a reduction of 10% in an individual with a probability of 0.95. |
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Authors:
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A Wasenius; M Stugaard; J E Otterstad; D Frøyshov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 50 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1991-01-08 Completed Date: 1991-01-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 635-42 Citation Subset: IM |
Affiliation:
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Medical Department, Vestfold Central Hospital, Tønsberg, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoproteins A / blood Apolipoproteins B / blood Apoproteins / blood* Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Circadian Rhythm* Female Humans Lipids / blood* Lipoproteins / blood* Male Middle Aged Time Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins A; 0/Apolipoproteins B; 0/Apoproteins; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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