Document Detail

Diurnal monitoring of blood pressure and the renin-angiotensin system in hypertensive patients on long-term angiotensin converting enzyme inhibition.
MedLine Citation:
PMID:  2170513     Owner:  NLM     Status:  MEDLINE    
The temporal blood pressure course and the diurnal profile of the renin-angiotensin system were examined in 13 patients with essential hypertension receiving hydrochlorothiazide and enalapril once daily. Blood samples were taken and blood pressure was measured before the habitual morning dose of hydrochlorothiazide and enalapril (at 8.00 a.m.) and at seven time points over the next 24 h. During the period of maximal effect of enalapril (from 11.00 a.m. to 2.00 p.m.), the increase in plasma renin concentration ranged from no change to an 800% increase. A negative correlation was observed between an increase in plasma renin and a decrease in immunoreactive plasma angiotensin II concentration (Spearman rank-order correlation coefficient = 0.83). Notably, the greatest changes in plasma renin and angiotensin II concentrations after enalapril were seen in those patients whose blood pressure fell most during the day. We conclude that hypertensive patients on long-term therapy with enalapril once daily vary widely in their between-dose biochemical response to the drug, and that there is a significant association between the responsiveness of the plasma renin-angiotensin system and the effect on 24 h blood pressure.
N Gadsbøll; M Damkjaer Nielsen; J Giese; A Leth; H Lønborg-Jensen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  8     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-11-14     Completed Date:  1990-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  733-40     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Blood Pressure / drug effects,  physiology
Circadian Rhythm / physiology
Drug Therapy, Combination
Enalapril / therapeutic use
Hydrochlorothiazide / therapeutic use
Hypertension / drug therapy*,  physiopathology
Middle Aged
Renin-Angiotensin System / drug effects,  physiology*
Time Factors
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 58-93-5/Hydrochlorothiazide; 75847-73-3/Enalapril

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