| Diurnal hormone variation in fibromyalgia syndrome: a comparison with rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 2607509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty patients with fibromyalgia syndrome and 20 patients with rheumatoid arthritis (RA) were assessed as outpatients over a 3 day period with respect to peak and trough levels of plasma cortisol, growth hormone, prolactin, ACTH and thyroid stimulating hormone. Patients with fibromyalgia syndrome had loss of diurnal variation in plasma cortisol (trough levels 347.3 +/- 254.7 vs 232.8 +/- 70.0 nmol/l, p less than 0.001) compared with RA patients. Thirty-five percent (7/20) of patients with fibromyalgia syndrome and only 5 percent (1/20) of those with RA exhibited abnormal dexamethasone suppression tests (p less than 0.001). No differences were noted in the diurnal variation of other hormones tested. Beck Depression Inventory scores were similar in both groups and no patient exhibited clinical evidence of depression. These data suggest alteration in the pituitary hypothalamic axis with respect to cortisol secretion in fibromyalgia syndrome, perhaps as a consequence of chronic pain. |
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Authors:
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G A McCain; K S Tilbe |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of rheumatology. Supplement Volume: 19 ISSN: 0380-0903 ISO Abbreviation: J Rheumatol Suppl Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1990-02-14 Completed Date: 1990-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806058 Medline TA: J Rheumatol Suppl Country: CANADA |
Other Details:
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Languages: eng Pagination: 154-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Western Ontario, London, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Rheumatoid
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blood,
diagnosis,
physiopathology* Circadian Rhythm* Dexamethasone / diagnostic use Fibromyalgia / blood, diagnosis, physiopathology* Growth Hormone / blood Humans Hydrocortisone / blood Pain Prolactin / blood Syndrome |
| Chemical | |
Reg. No./Substance:
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50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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