Document Detail


Diurnal blood pressure variations in incipient and end stage diabetic renal disease.
MedLine Citation:
PMID:  10808057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our aim was to compare the diurnal blood pressure patterns of people with Type 1 diabetes on continuous ambulatory peritoneal dialysis (CAPD, n=9) or haemodialysis (n=10) to diabetic patients with normo-albuminuria (n=12) or micro-albuminuria (n=15). Blood pressure was measured with an ABPM02 Meditech oscillometric blood pressure monitor. The micro-albuminuric group had significantly higher nocturnal diastolic and mean arterial pressures than the normo-albuminuric group. CAPD and haemodialysis patients had significantly higher day time, nocturnal mean systolic, diastolic and mean arterial blood pressures. Micro-albuminuric and end-stage renal failure patients displayed a loss of the physiological drop of systolic blood pressure, which was only significant in the normo-albuminuric group. Nocturnal drop of blood pressure characterised by diurnal indices were 7.4% in the CAPD, 8.8% in the haemodialysis, 10.0% in the micro-albuminuric and 16.5% in the normo-albuminuric group. These results suggest, that pathological circadian blood pressure variation is common in diabetic patients on dialysis, and ambulatory blood pressure monitoring can be a useful tool both in its the detection and its adequate treatment.
Authors:
L Tóth; P Vörös; Z Lengyel; M Liptai; C Németh; L Kammerer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  49     ISSN:  0168-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-07     Completed Date:  2000-09-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Affiliation:
Second Department of Medicine, Szent István Hospital, II. Belgyógyászat, Nagyvárad tér 1, 1096, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adult
Albuminuria / blood,  urine
Blood Glucose / analysis
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Blood Urea Nitrogen
C-Peptide / blood
Cholesterol / blood
Circadian Rhythm
Creatinine / blood
Diabetes Mellitus, Type 1 / blood,  complications*,  physiopathology
Diabetic Nephropathies / blood,  complications*,  physiopathology
Female
Hemoglobin A, Glycosylated / analysis
Humans
Hypertension / complications*,  physiopathology
Kidney Failure, Chronic / blood,  complications*,  physiopathology,  therapy
Male
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory
Renal Dialysis
Triglycerides / blood
beta 2-Microglobulin / blood,  urine
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 0/Hemoglobin A, Glycosylated; 0/Triglycerides; 0/beta 2-Microglobulin; 57-88-5/Cholesterol; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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