Document Detail

Diurnal changes in urinary excretion of IgG, transferrin, and ceruloplasmin depend on diurnal changes in systemic blood pressure in normotensive, normoalbuminuric type 2 diabetic patients.
MedLine Citation:
PMID:  19670106     Owner:  NLM     Status:  MEDLINE    
Previous studies of diabetic patients indicate that increased urinary excretion of certain plasma proteins (molecular radii <55 A), such as IgG, transferrin, and ceruloplasmin, precede the development of microalbuminuria. Moreover, increases in these urinary proteins predict future development of microalbuminuria. To clarify whether blood pressure changes influence urinary excretion of these proteins, we examined relationships between diurnal blood pressure changes measured by ambulatory blood pressure monitoring and urinary excretion of IgG, transferrin, ceruloplasmin, alpha2-macroglobulin (88 A) and albumin (36 A) measured separately during the day and night in 20 healthy controls and 26 normotensive, normoalbuminuric diabetic patients. Diurnal change in systolic blood pressure was not correlated to urinary excretion of either albumin or alpha2-macroglobulin in either diabetic patients or controls. However, statistically significant correlations between diurnal changes in systolic blood pressure and those of urinary excretion of IgG, transferrin and ceruloplasmin were found in diabetic patients but not in controls. The present findings suggest that urinary excretion of IgG, transferrin, and ceruloplasmin are more easily affected than albuminuria by systemic blood pressure changes in normoalbuminuric diabetic patients. This is supported by our previous finding that urinary excretion of IgG, transferrin and ceruloplasmin increased while albuminuria did not following enhanced glomerular filtration rate after acute protein loading, which causes increased glomerular capillary pressure due to afferent arterioles dilation, mimicking diabetic intra-renal hemodynamics. Taken together, these findings suggest that urinary excretion of IgG, transferrin, and ceruloplasmin may be more sensitive indicators of glomerular capillary pressure change than albuminuria in normoalbuminuric diabetic patients.
M Hosoba; H Fujita; T Miura; T Morii; T Shimotomai; J Koshimura; Y Yamada; S Ito; T Narita
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-08-07
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et m?tabolisme     Volume:  41     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  910-5     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart. New York.
Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University School of Medicine, 010-8543 Akita, Japan.
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MeSH Terms
Albuminuria / urine
Blood Pressure / physiology*
Blood Proteins / urine
Case-Control Studies
Ceruloplasmin / urine*
Circadian Rhythm / physiology*
Diabetes Mellitus, Type 2 / physiopathology*,  urine*
Immunoglobulin G / urine*
Middle Aged
Transferrin / urine*
Reg. No./Substance:
0/Blood Proteins; 0/Immunoglobulin G; 11096-37-0/Transferrin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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