| Diuretics in acute kidney injury. | |
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MedLine Citation:
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PMID: 22099509 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Acute kidney injury (AKI) is common in hospitalized patients and is associated with significant morbidity and mortality. The incidence of AKI is increasing and despite clinical advances there has been little change in the outcomes associated with AKI. A variety of interventions, including loop diuretics, have been tested for the prevention and treatment of AKI; however, none to date have shown convincing benefits in clinical studies, and the management of AKI remains largely supportive. In this article, we review the pharmacology and experimental and clinical evidence for loop diuretics in the management of AKI. In addition, we also review evidence for other agents with diuretic and/or natriuretic properties such as thiazide diuretics, mannitol, fenoldopam, and natriuretic peptides in both the prevention and treatment of AKI. Implications for current clinical practice are outlined to guide clinical decisions in this field. |
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Authors:
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Sagar U Nigwekar; Sushrut S Waikar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in nephrology Volume: 31 ISSN: 1558-4488 ISO Abbreviation: Semin. Nephrol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 523-34 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Nephrology, Massachusetts General Hospital, Boston, MA and Scholars in Clinical Science Program, Harvard Medical School, Boston, MA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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