Document Detail

Diuretics aggravate zinc deficiency in patients with liver cirrhosis by increasing zinc excretion in urine.
MedLine Citation:
PMID:  22994500     Owner:  NLM     Status:  Publisher    
AIM: Liver cirrhosis is often accompanied by zinc deficiency. The exact mechanisms underlying zinc deficiency remain unclear. This study was undertaken to clarify the influence of diuretics on blood zinc levels and zinc excretion in urine in liver cirrhosis. METHODS: Seventy-nine outpatients with liver cirrhosis were divided into four groups: (i) patients receiving no zinc preparations or diuretics (LC group); (ii) those receiving zinc preparations only (LCZ group); (iii) those receiving diuretics only (LCD group); and (iv) those receiving both zinc preparations and diuretics (LCDZ group). Among these groups, the effects of the administrated drugs on blood zinc levels and urinary zinc excretion were analyzed. RESULTS: Blood zinc levels were significantly lower in the LCD group (47.8  10.5 μg/dL) than in the other groups (LC: 68.8  17.1 μg/dL, P = 0.0056, post-hoc test; LCZ: 78.4  18.1, P < 0.0001; LCDZ: 70.3  21.4, P = 0.0008). The creatinine-adjusted urinary zinc excretion was significantly higher in the LCDZ group (548.1  407.6 μg/mg creatinine) than in the other groups (LC, 58.5  43.7; LCZ, 208.1  227.8; LCD, 105.2  154.4; each P < 0.0001). The fraction of urinary zinc excretion was also significantly higher in the LCDZ group (5.6  2.9%) than in the other groups (LC, 0.6  0.5; LCD, 1.7  1.5; LCZ, 1.6  1.2; each P < 0.0001). CONCLUSION: In patients with liver cirrhosis, treatment with diuretics can increase zinc excretion by suppressing the reabsorption of zinc through renal tubules, which might lead to zinc deficiency.
Miho Chiba; Kazuhiro Katayama; Risato Takeda; Rie Morita; Kiyoshi Iwahashi; Yoshiki Onishi; Hisaaki Kita; Akira Nishio; Tomoyo Kanno; Tamiko Saito; Kosaku Maeda; Masafumi Naito; Tomoki Michida; Toshifumi Ito
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-20
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  -     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Japan Society of Hepatology.
Department of Internal Medicine, Osaka Koseinenkin Hospital.
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