| Diuretic usage in heart failure: a continuing conundrum in 2005. | |
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MedLine Citation:
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PMID: 15734765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several large well-designed clinical trials have shown that the use of diuretics is beneficial in patients with hypertension. However, similarly robust data regarding their role in chronic heart failure are lacking. Historically, diuretics were developed for treatment of sodium and water retention in oedematous disorders and clinically, they remain the most potent drugs available to relieve symptoms and eliminate oedema in the congested patient with heart failure. In the non-congested patient, however, diuretics continue to be used on a purely clinical basis without sufficient characterization of benefits, adverse effects, and potential influence on mortality. There are also concerns that chronic diuretic usage can cause adverse vascular effects, unfavourable neuroendocrine activation, electrolyte imbalances, and life-threatening arrhythmias. In this article, we review the limited evidence available regarding the benefits and perils of using diuretics in heart failure. |
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Authors:
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S Gupta; L Neyses |
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Publication Detail:
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Type: Journal Article; Review Date: 2005-02-25 |
Journal Detail:
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Title: European heart journal Volume: 26 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-21 Completed Date: 2005-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 644-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Wythenshawe Hospital, Manchester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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chemically induced Cardiac Output, Low / drug therapy*, physiopathology Diuretics / adverse effects, therapeutic use* Heart Failure / drug therapy*, physiopathology Hemodynamics / drug effects* Hospitalization Humans Neurosecretory Systems / drug effects Prognosis Quality of Life Substance Withdrawal Syndrome / physiopathology Water-Electrolyte Imbalance / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Diuretics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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