Document Detail

Diuretic-induced dehydration/hypovolemia inhibits thermal panting in rabbits.
MedLine Citation:
PMID:  16309974     Owner:  NLM     Status:  MEDLINE    
Respiratory and thermoregulatory responses to hyperthermia during isosmotic dehydration/hypovolemia were studied in 17 anaesthetized adult rabbits divided into two groups: normovolemic group (NV; n=10) and hypovolemic group (HV; n=7). Hypovolemia/isosmotic dehydration (a decrease in plasma volume by 16.1+/-1.2%) was induced by furosemide (5 mg kg(-1) i.v.). During hyperthermia (the rise in body temperature to 42 degrees C by a gradual body surface heating), the HV rabbits had lower (P<0.05) respiratory frequency and higher (P<0.05) tidal volume than the NV animals. The panting was absent in the HV rabbits at the BT of 42 degrees C, unlike the NV animals. The lower respiratory frequency and the absence of panting during exogenous hyperthermia in dehydrated animals are present not only during hyperosmotic dehydration induced by water deprivation [Doris, P.A., Baker, M.A., 1981. Hypothalamic control of thermoregulation during dehydration. Brain Res. 206 (1), 219-222], but they also occur in the furosemide-induced isosmotic dehydration/hypovolemia.
Andrea Brozmanova; Jerzy Jochem; Kamil Javorka; Ivan Zila; Krystyna Zwirska-Korczala
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-11-23
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  150     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  99-102     Citation Subset:  IM    
Department of Physiology, Comenius University, Jessenius Faculty of Medicine, Malá Hora 4, 037 54 Martin, Slovakia.
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MeSH Terms
Blood Gas Analysis
Body Temperature Regulation*
Dehydration / blood,  chemically induced,  physiopathology*
Diuretics / adverse effects
Furosemide / adverse effects
Respiration* / drug effects
Tidal Volume / drug effects,  physiology
Reg. No./Substance:
0/Diuretics; 54-31-9/Furosemide

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