Document Detail


Diuretic, hypotensive, and hypocholesterolemic effects of Eclipta alba in mild hypertensive subjects: a pilot study.
MedLine Citation:
PMID:  17472478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The combined effect of dried Eclipta alba leaf powder (3 g/day) in encapsulated form on blood pressure, diuresis, and lipid profile of 60 mildly hypertensive male subjects in the age group of 40-55 years was studied. The subjects were divided into two groups, i.e., a control (placebo) and the Eclipta group, and were given six capsules (500 mg each) per day in three equal doses for a period of 60 days. Clinical parameters, viz., blood pressure, urine volume, electrolytes (Na and K) in serum and urine, lipid profile, and plasma lipid peroxides, were analyzed before and after the feeding trials. The findings revealed that the Eclipta-supplemented group showed a marked reduction in mean arterial pressure by 15%, total cholesterol (17%), low-density lipoprotein fraction (24%), triglycerides (14%), very-low-density lipoprotein fraction (14%), and plasma lipid peroxides (18%). Results also revealed a remarkable increase in urine volume (34%), urine sodium (24%), serum vitamin C (17%), and serum tocopherols (23%) of the Eclipta group. In conclusion, it would appear that E. alba is diuretic, hypotensive, and hypocholesterolemic and helps in the alleviating oxidative stress-induced complications in hypertensives.
Authors:
Vasavi Rangineni; D Sharada; Saileshnath Saxena
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal food     Volume:  10     ISSN:  1096-620X     ISO Abbreviation:  J Med Food     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-05-02     Completed Date:  2007-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-8     Citation Subset:  IM    
Affiliation:
Department of Foods and Nutrition, Post Graduate and Research Center, Acharya NG Ranga Agricultural University, Erragadda, Hyderabad, India. vasavi_16@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticholesteremic Agents / administration & dosage*
Antihypertensive Agents / administration & dosage*
Ascorbic Acid / blood
Blood Pressure / drug effects
Diuresis / drug effects
Diuretics / administration & dosage*
Eclipta / chemistry*
Humans
Hypertension / drug therapy*
Lipid Peroxides / blood
Lipids / blood
Male
Middle Aged
Natriuresis / drug effects
Phytotherapy
Placebos
Plant Extracts / administration & dosage*
Plant Leaves / adverse effects,  chemistry
Tocopherols / blood
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Antihypertensive Agents; 0/Diuretics; 0/Lipid Peroxides; 0/Lipids; 0/Placebos; 0/Plant Extracts; 1406-66-2/Tocopherols; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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