Document Detail

Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in anesthetized dogs.
MedLine Citation:
PMID:  7735202     Owner:  NLM     Status:  MEDLINE    
The effects of intravenous infusion of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), a novel adenosine A1-receptor antagonist, on urine volume, urinary excretion of electrolytes and renal hemodynamics were examined in anesthetized dogs. KW-3902 at 10 and 30 micrograms/kg/min for 20 min inhibited the decline of renal blood flow induced by intrarenal arterial injection of adenosine (0.5-2.0 micrograms). KW-3902 at these doses produced significant increases in urine volume and sodium excretion with little change in potassium excretion. The diuretic effect of KW-3902 at 30 micrograms/kg/min for 20 min continued for longer than 1 h even after discontinuation of the KW-3902 infusion. KW-3902 did not affect creatinine clearance, renal blood flow, arterial blood pressure or heart rate. Furosemide at 10 micrograms/kg/min for 20 min brought about significant increases in urine volume and excretion of sodium and potassium. The diuresis and saliuresis induced by furosemide continued for only 40 min after discontinuation of the drug infusion. Trichlormethiazide at 3 micrograms/kg/min for 20 min also provoked increases in urine volume and sodium excretion, but did not affect potassium excretion. The diuretic and natriuretic effect of trichlormethiazide gradually disappeared after discontinuation of the drug infusion. The present study in anesthetized dogs suggests that KW-3902, an adenosine A1-receptor antagonist, produces diuresis and natriuresis but not kaliuresis and that the diuresis and natriuresis are caused in large part by the inhibition of sodium reabsorption at tubular sites.
T Yamagata; T Kobayashi; H Kusaka; A Karasawa
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  17     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1599-603     Citation Subset:  IM    
Department of Pharmacology, Pharmaceutical Research Laboratories, Kogyo Co., Ltd., Shizuoka, Japan.
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MeSH Terms
Diuretics / pharmacology*
Electrolytes / urine
Furosemide / pharmacology
Glomerular Filtration Rate / drug effects
Hemodynamics / drug effects
Receptors, Purinergic P1 / antagonists & inhibitors*
Renal Circulation / drug effects
Trichlormethiazide / pharmacology
Urodynamics / drug effects
Xanthines / pharmacology*
Reg. No./Substance:
0/Diuretics; 0/Electrolytes; 0/Receptors, Purinergic P1; 0/Xanthines; 133-67-5/Trichlormethiazide; 136199-02-5/1,3-dipropyl-8-(3-noradamantyl)xanthine; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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