Document Detail

Disulfite-induced acute intermittent urticaria with vasculitis.
MedLine Citation:
PMID:  8274792     Owner:  NLM     Status:  MEDLINE    
Recognition of sulfite sensitivity by the practicing dermatologist has become increasingly important. A wide spectrum of anaphylactoid reactions can occur after ingestion of sulfite additives in foods and medications. We report the case of a 47-year-old man with severe acute intermittent urticaria. A placebo-controlled oral challenge test with 50 mg sodium disulfite resulted in an acute urticaria attack. A biopsy taken 5 h after the appearance of the urticaria demonstrated a leukocytoclastic vasculitis with eosinophilia. Avoiding foods and drugs containing sulfites is often difficult due to its widespread use. Therefore, the patient should be equipped with a medical emergency kit.
B Wüthrich; M K Kägi; J Hafner
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  187     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  1993  
Date Detail:
Created Date:  1994-02-10     Completed Date:  1994-02-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  290-2     Citation Subset:  IM    
Department of Dermatology University Hospital, Zurich, Switzerland.
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MeSH Terms
Angioedema / chemically induced
Dyspnea / chemically induced
Eosinophilia / chemically induced
Food Additives / adverse effects*
Middle Aged
Pharmaceutic Aids / adverse effects*
Sulfites / adverse effects*
Urticaria / chemically induced*
Vasculitis, Leukocytoclastic, Cutaneous / chemically induced*
Reg. No./Substance:
0/Food Additives; 0/Pharmaceutic Aids; 0/Placebos; 0/Sulfites; 7681-57-4/sodium metabisulfite

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