| Disulfiram-like syndrome after hydrogen cyanamide professional skin exposure: two case reports in France. | |
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MedLine Citation:
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PMID: 19657887 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Hydrogen cyanamide is a plant growth regulator used in agriculture to induce bud break in fruit trees. Contact with the skin can result in percutaneous absorption of the substance that inhibits aldehyde dehydrogenase and can induce acetaldehyde syndrome in case of alcohol use. The purpose of this report is to describe two cases of a disulfiram-like syndrome following occupational exposure to hydrogen cyanamide. The first case involved a 59-year-old man who used Dormex, which contains hydrogen cyanamide, without protection after consuming a large amount of alcohol during a meal. In less than 1 hour after the ingestion of alcohol, he developed malaise with flushing of the face, tachycardia, and dyspnea. Manifestations regressed spontaneously under surveillance in the hospital. The second case occurred in a 55-year-old farmer following cutaneous contact with Dormex. Five hours after exposure, he developed disulfiram-like syndrome with flushing, tachycardia, and arterial hypotension after consuming three glasses of wine. The patient recovered spontaneously in 3 hours under surveillance in the hospital. These cases confirm the necessity of avoiding alcohol consumption as recommended in the instructions for use of Dormex and of preventing cutaneous contact during use. |
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Authors:
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Luc de Haro |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of agromedicine Volume: 14 ISSN: 1545-0813 ISO Abbreviation: J Agromedicine Publication Date: 2009 |
Date Detail:
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Created Date: 2009-08-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421530 Medline TA: J Agromedicine Country: United States |
Other Details:
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Languages: eng Pagination: 382-4 Citation Subset: IM |
Affiliation:
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Centre Antipoison, Hôpital Salvator, Marseille, France. luc.deharo@ap-hm.fr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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