Document Detail

Disulfiram, an option for the treatment of pathological gambling?
MedLine Citation:
PMID:  20083479     Owner:  NLM     Status:  MEDLINE    
AIM: Pathological gambling and comorbid alcohol dependence often occur in combination. Disulfiram is one of the proven drugs for alcohol dependence. In addition to its inhibiting acetaldehyde dehydrogenase, disulfiram inhibits dopamine beta-hydroxylase and may thereby increase dopamine and decrease norepinephrine cerebral concentrations. Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling. METHOD: We describe the outcome of a patient with alcohol dependence and pathological gambling treated with disulfiram D. RESULTS: During treatment with disulfiram, the patient reported that his desire to gamble disappeared entirely. Follow-up indicated that he has not gambled for >12 months. CONCLUSIONS: Although uncontrolled case observations should be interpreted with caution, disulfiram deserves further investigation in pathological gambling.
Jochen Mutschler; Mira B?hler; Martin Grosshans; Alexander Diehl; Karl Mann; Falk Kiefer
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-18
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  45     ISSN:  1464-3502     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  England    
Other Details:
Languages:  eng     Pagination:  214-6     Citation Subset:  IM    
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5 68159 Mannheim, Germany.
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MeSH Terms
Alcohol Deterrents / adverse effects,  therapeutic use*
Alcoholism / rehabilitation*
Behavior Therapy
Combined Modality Therapy
Disulfiram / adverse effects,  therapeutic use*
Follow-Up Studies
Gambling / psychology*
Impulse Control Disorders / rehabilitation*
Middle Aged
Recurrence / prevention & control
Rehabilitation Centers
Temperance / psychology
Reg. No./Substance:
0/Alcohol Deterrents; 97-77-8/Disulfiram

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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