| Disturbed zinc metabolism and reduced birthweight related to raised maternal serum alpha-fetoprotein in normal human pregnancies. | |
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MedLine Citation:
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PMID: 7529457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothesis was examined that altered maternal zinc metabolism is involved in the low birthweight associated with raised maternal serum alpha-fetoprotein (MSAFP). Mothers with clinically normal pregnancy and normally formed infant but with raised MSAFP (> 90th percentile) had lower than normal plasma zinc concentration, raised leucocyte zinc and disturbed zinc-albumin relationship. They delivered offspring with lower birthweights than did women with normal MSAFP concentration, due both to shorter pregnancy and slower intrauterine growth. These results and others identify a subgroup of mothers associated with low infant birthweight, those with raised MSAFP, who have altered zinc distribution. |
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Authors:
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D L Bloxam; N R Williams; R J Waskett; S G Stewart |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 73 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1995-02-08 Completed Date: 1995-02-08 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 758-64 Citation Subset: IM |
Affiliation:
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Reproductive Biology Laboratory, Royal Postgraduate Medical School, Queen Charlotte's and Chelsea Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Growth Retardation / etiology* Humans Infant, Low Birth Weight* Infant, Newborn Infant, Premature Obstetric Labor, Premature Pregnancy / blood, metabolism* Zinc / blood, metabolism* alpha-Fetoproteins / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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