Document Detail

Disturbed zinc metabolism and reduced birthweight related to raised maternal serum alpha-fetoprotein in normal human pregnancies.
MedLine Citation:
PMID:  7529457     Owner:  NLM     Status:  MEDLINE    
The hypothesis was examined that altered maternal zinc metabolism is involved in the low birthweight associated with raised maternal serum alpha-fetoprotein (MSAFP). Mothers with clinically normal pregnancy and normally formed infant but with raised MSAFP (> 90th percentile) had lower than normal plasma zinc concentration, raised leucocyte zinc and disturbed zinc-albumin relationship. They delivered offspring with lower birthweights than did women with normal MSAFP concentration, due both to shorter pregnancy and slower intrauterine growth. These results and others identify a subgroup of mothers associated with low infant birthweight, those with raised MSAFP, who have altered zinc distribution.
D L Bloxam; N R Williams; R J Waskett; S G Stewart
Related Documents :
2668917 - Prenatal screening and diagnosis of neural tube defects in england and wales in 1985.
17714997 - Fetal surgery for neural tube defects.
1279657 - Alpha-fetoprotein levels and yolk sac size in the first trimester of pregnancy.
17154227 - Fetal anomaly scan potentially will replace routine afafp assays for the detection of n...
16736057 - Residential mobility patterns and exposure misclassification in epidemiologic studies o...
886827 - Problems of undernutrition research with breeding mice.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  73     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-02-08     Completed Date:  1995-02-08     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  758-64     Citation Subset:  IM    
Reproductive Biology Laboratory, Royal Postgraduate Medical School, Queen Charlotte's and Chelsea Hospital, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Fetal Growth Retardation / etiology*
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature
Obstetric Labor, Premature
Pregnancy / blood,  metabolism*
Zinc / blood,  metabolism*
alpha-Fetoproteins / analysis*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/alpha-Fetoproteins; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The carbohydrate epitope 3-fucosyl-N-acetyllactosamine is region-specifically expressed in astrocyte...
Next Document:  The survival of cultured mouse cerebellar granule cells is not dependent on elevated potassium-ion c...