Document Detail


Disturbed zinc metabolism and reduced birthweight related to raised maternal serum alpha-fetoprotein in normal human pregnancies.
MedLine Citation:
PMID:  7529457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothesis was examined that altered maternal zinc metabolism is involved in the low birthweight associated with raised maternal serum alpha-fetoprotein (MSAFP). Mothers with clinically normal pregnancy and normally formed infant but with raised MSAFP (> 90th percentile) had lower than normal plasma zinc concentration, raised leucocyte zinc and disturbed zinc-albumin relationship. They delivered offspring with lower birthweights than did women with normal MSAFP concentration, due both to shorter pregnancy and slower intrauterine growth. These results and others identify a subgroup of mothers associated with low infant birthweight, those with raised MSAFP, who have altered zinc distribution.
Authors:
D L Bloxam; N R Williams; R J Waskett; S G Stewart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  73     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-02-08     Completed Date:  1995-02-08     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  758-64     Citation Subset:  IM    
Affiliation:
Reproductive Biology Laboratory, Royal Postgraduate Medical School, Queen Charlotte's and Chelsea Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fetal Growth Retardation / etiology*
Humans
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature
Obstetric Labor, Premature
Pregnancy / blood,  metabolism*
Zinc / blood,  metabolism*
alpha-Fetoproteins / analysis*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/alpha-Fetoproteins; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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