| Disturbed surface properties in preterm infants with pneumonia. | |
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MedLine Citation:
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PMID: 11223646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital pneumonia in preterm infants is often associated with respiratory insufficiency requiring mechanical ventilation. This study was performed to show whether pneumonia in these infants is associated with an inhibition or deficiency of surfactant. The ratio of lecithin and sphingomyelin (L/S ratio) and minimal surface tension were determined in pharyngeal aspirates from 90 term born infants (healthy) and in tracheal aspirates from preterm infants with wet lung (n = 13), congenital pneumonia (n = 21) and respiratory distress syndrome (RDS) (n = 90). The L/S ratio was lower (p < 0.0001) in the RDS group (8.6) when compared with healthy (48.6), wet lung (42.9) and pneumonia (28.9). Surface tension was higher (p < 0.001) in RDS (37 mN/m) and pneumonia (33.7) when compared with healthy (22.9) or wet lung (21.2). For infants with RDS, L/S ratio <16.5 detects surfactant deficiency with 96% specificity and 70% sensitivity, surface tension >29 mN/m represents surfactant inhibition (specificity 97%, sensitivity 92%). Using these cut-off values in infants with pneumonia, 81% had a sufficient amount of surfactant but only 21% of infants with pneumonia had appropriate surface tension. Our study shows that lung effluent of respiratory insufficient infants with pneumonia, who need mechanical ventilation, has disturbed surface properties despite a sufficient amount of surfactant. In these infants, surfactant substitution could be beneficial. |
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Authors:
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M Rüdiger; W Friedrich; B Rüstow; G Schmalisch; R Wauer |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biology of the neonate Volume: 79 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: Switzerland |
Other Details:
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Languages: eng Pagination: 73-8 Citation Subset: IM |
Copyright Information:
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Copyright 2001 S. Karger AG, Basel |
Affiliation:
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Otto Heubner Center for Pediatrics, Clinic of Neonatology, Charité Campus Mitte, Hospital of Humboldt University, Berlin, Germany. mario.ruediger@rz.hu-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Humans Infant, Newborn Infant, Premature* Lung / metabolism Phosphatidylcholines / metabolism Pneumonia / congenital, physiopathology* Prospective Studies Pulmonary Surfactants / physiology* Reference Values Respiratory Distress Syndrome, Newborn / physiopathology Sphingomyelins / metabolism Surface Tension |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 0/Pulmonary Surfactants; 0/Sphingomyelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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