Document Detail

Disturbed stress responses in women with polycystic ovary syndrome.
MedLine Citation:
PMID:  19150179     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We analyzed the neuroendocrine and immune cell responses to psychosocial stress in PCOS patients compared to BMI-matched healthy controls. METHODS: Responses to public speaking stress were analyzed in 32 PCOS patients and 32 BMI-matched healthy controls. At baseline, during, and 10- and 45-min after stress, state anxiety, cardiovascular responses, cortisol, ACTH, as well as circulating leukocyte subpopulations were analyzed, together with hsCRP and serum IL-6 concentrations. RESULTS: In response to public speaking stress, both groups showed significant but comparable increases in state anxiety, and blood pressure (all p<0.001; time effects). The ACTH and cortisol stress responses were significantly enhanced in PCOS (both p<0.05; interaction effect). In addition, heart rate was significantly higher in PCOS (p<0.05; group effect). PCOS patients displayed a reduced upregulation of IL-6 levels in response to stress (p<0.05; interaction effect). Baseline levels of circulating leukocyte subpopulations, IL-6 and hsCRP concentrations did not differ between BMI-matched controls and PCOS patients. PCOS patients were characterized by markedly increased psychological distress. CONCLUSIONS: PCOS patients showed enhanced HPA-axis and heart rate reactivity as well as a reduced upregulation of IL-6 in response to stress. The altered stress reactivity in PCOS patients may constitute a link between depression, overweight, and the cardiovascular and diabetes risks associated with the diagnosis.
S Benson; P C Arck; S Tan; S Hahn; K Mann; N Rifaie; O E Janssen; M Schedlowski; S Elsenbruch
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-15
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  34     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  727-35     Citation Subset:  IM    
Department of Medical Psychology and Behavioral Immunobiology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany.
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MeSH Terms
Anxiety / complications,  physiopathology
Blood Pressure / drug effects
Heart Rate / drug effects
Hypoglycemic Agents / pharmacology,  therapeutic use
Hypothalamo-Hypophyseal System / drug effects,  metabolism,  physiopathology*
Metformin / pharmacology,  therapeutic use
Pituitary-Adrenal System / drug effects,  metabolism,  physiopathology*
Polycystic Ovary Syndrome / complications,  drug therapy,  physiopathology*
Speech / physiology
Stress, Psychological / complications,  physiopathology*
Reg. No./Substance:
0/Hypoglycemic Agents; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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