Document Detail

Disturbed solid-phase gastric emptying in functional dyspepsia: a meta-analysis.
MedLine Citation:
PMID:  9753269     Owner:  NLM     Status:  MEDLINE    
Functional dyspepsia is a common disorder with a diverse pathophysiological background, but the role of motility disorders in functional dyspepsia remains unclear. We aimed to quantify the relationship between disturbed gastric emptying and functional dyspepsia, using a meta-analytic approach. Through a structured literature search of Medline and Embase from 1983 to 1996, we selected all studies in which scintigraphic solid-phase gastric emptying was measured in both functional dyspeptic patients and controls. Seventeen studies involving 868 dyspeptic patients and 397 controls were pooled. Gastric emptying in patients with functional dyspepsia was 1.46 (1.23-1.69) times slower than controls; the proportion of patients with abnormally slow emptying was either 37% (34-40%, simple numeric pooling) or 39% (29-49%, weighted pooling). We conclude that gastric emptying of solids in patients with functional dyspepsia is 1.5 times slower than in healthy controls and that a significant delay of emptying is present in almost 40% of patients with functional dyspepsia.
A O Quartero; N J de Wit; A C Lodder; M E Numans; A J Smout; A W Hoes
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  43     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-09     Completed Date:  1998-10-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2028-33     Citation Subset:  AIM; IM    
Department of General Practice, Universiteit Utrecht, The Netherlands.
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MeSH Terms
Dyspepsia / etiology*,  physiopathology*
Gastric Emptying*
Gastrointestinal Motility

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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