Document Detail

Disturbed prolactin responses to dopamine-related substances in patients with acromegaly and hyperprolactinemia.
MedLine Citation:
PMID:  4042986     Owner:  NLM     Status:  MEDLINE    
We undertook this study, because conflicting data were reported about the dopaminergic regulation of prolactin (PRL) secretion in patients with acromegaly and hyperprolactinemia. In order to clarify the dopaminergic regulation of PRL secretion in patients with acromegaly and hyperprolactinemia, the effects of nomifensine, a central dopamine agonist, FK 33-824, a centrally antidopaminergically acting agent, and domperidone, a peripheral dopamine antagonist, on plasma PRL in these patients were studied. The results were compared with those observed in normal subjects and hyperprolactinemic patients, with or without a pituitary tumor. Nomifensine did not lower the PRL levels and FK 33-824 did not raise the PRL levels in acromegalic patients. In hyperprolactinemic patients, nomifensine did not lower the PRL levels and FK 33-824 failed to raise the PRL levels. Domperidone did not increase PRL in about a third of acromegalic patients, while TRH increased PRL in the all normoprolactinemic acromegalic patients. These results suggest that in acromegalic patients there may be a disturbance in dopamine related neurotransmission and that such disorders also seem to be present in patients with hyperprolactinemia, with or without a pituitary tumor.
K Sekiya; T Karashima; S Ikuyama; K Muta; K Kato; H Ibayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinologia japonica     Volume:  32     ISSN:  0013-7219     ISO Abbreviation:  Endocrinol. Jpn.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-10-31     Completed Date:  1985-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376546     Medline TA:  Endocrinol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  207-14     Citation Subset:  IM    
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MeSH Terms
Acromegaly / blood*
D-Ala(2),MePhe(4),Met(0)-ol-enkephalin / pharmacology*
Domperidone / pharmacology
Middle Aged
Nomifensine / pharmacology*
Pituitary Neoplasms / blood
Prolactin / blood*
Reg. No./Substance:
24526-64-5/Nomifensine; 57808-66-9/Domperidone; 64854-64-4/D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; 9002-62-4/Prolactin

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