Document Detail

Disturbed planum temporale asymmetry in schizophrenia. A quantitative post-mortem study.
MedLine Citation:
PMID:  7710997     Owner:  NLM     Status:  MEDLINE    
The planum temporale of the temporal cortex was investigated post-mortem in 24 schizophrenic patients and 24 age- and sex-matched control subjects. Schizophrenic patients demonstrated a 20% volume reduction of the left planum temporale (p = 0.032), whereas on the right side, there was a trend for increase in male schizophrenics (+22%, p = 0.17), while in female patients the volume was moderately decreased (-6%, p = 0.74). The mean anterior-posterior diameter of the planum temporale was significantly reduced in the left hemisphere (-20%, p = 0.008), but unchanged on the right side. The asymmetry coefficients (Galaburda et al. (1987) Neuropsychologia 25, 853-868) for the planum temporale cortex volume (p = 0.02) and anterior-posterior diameter (p = 0.002) but not for mean area (p = 0.61) were significantly different between schizophrenics and control subjects. These data support the idea of disturbed cerebral laterality in schizophrenia. The implications of methodology and patient samples are discussed.
P Falkai; B Bogerts; T Schneider; B Greve; U Pfeiffer; K Pilz; C Gonsiorzcyk; C Majtenyi; I Ovary
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Schizophrenia research     Volume:  14     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-18     Completed Date:  1995-05-18     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  161-76     Citation Subset:  IM    
Department of Psychiatry, University of Düsseldorf, Germany.
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MeSH Terms
Brain Mapping
Dominance, Cerebral / physiology*
Middle Aged
Psychiatric Status Rating Scales
Reference Values
Schizophrenia / pathology*
Schizophrenic Psychology*
Sex Factors
Temporal Lobe / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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