| Disturbed noradrenergic blood pressure control in normotensive members of hypertensive families. | |
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MedLine Citation:
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PMID: 6696808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The possible influence of a family history of hypertension on some variables of adrenergic blood pressure regulation was assessed. Blood pressure, heart rate, plasma renin activity, adrenaline and noradrenaline concentrations, and plasma or urinary electrolyte estimations did not differ significantly between two groups of normotensive subjects matched for age and sex with and without a family history of hypertension. Compared with subjects without a family history, however, an appreciably decreased pressor dose of infused noradrenaline, a distinct shift to the left in the relation between noradrenaline induced changes in mean arterial pressure and concomitant plasma noradrenaline concentrations, and an enhanced pressor response to given increases in plasma noradrenaline concentrations occurred in the group with a family history. These findings suggest that an imbalance between cardiovascular noradrenaline responsiveness and circulating noradrenaline is a common familial disturbance which could possibly predispose to the development of essential hypertension. |
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Authors:
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M G Bianchetti; P Weidmann; C Beretta-Piccoli; U Rupp; K Boehringer; L Link; C Ferrier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British heart journal Volume: 51 ISSN: 0007-0769 ISO Abbreviation: Br Heart J Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-04-19 Completed Date: 1984-04-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370634 Medline TA: Br Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 306-11 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure* Female Heart Rate / drug effects Humans Hypertension / genetics*, physiopathology Male Norepinephrine / blood*, pharmacology |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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