Document Detail

Disturbed fat absorption following infectious gastroenteritis in children.
MedLine Citation:
PMID:  381617     Owner:  NLM     Status:  MEDLINE    
Fat absorption was studied in 10 patients recovering from an episode of acute infectious gastroenteritis who failed to gain weight despite adequate caloric intake. Three patients restudied after clinical improvement and three other infants with failure to thrive, unrelated to gastrointestinal problems, served as control subjects. Fat balance studies during the ingestion of a formula containing long-chain fatty acids demonstrated significant degrees of steatorrhea in patients (mean CFA 70.6 +/- 10.7 compared to 90.3 +/- 2.4 in control subjects). The administration of a test meal demonstrated a marked deficiency of duodenal bile acid concentration and of fat incorporation into the micellar phase in patients. Fecal bile acid excretion was significantly increased in patients (mean 33.9 +/- 11.6 microM/kg/day) as compared to control subjects (mean 13.5 +/- 3.1 microM/kg/day). Bacterial overgrowth and abnormalities of the small intestinal mucosa were not constant. Ileal dysfunction and associated bile acid loss are possible causes of disturbed fat assimilation following acute intestinal infection in children.
A Jonas; S Avigad; A Diver-Haber; D Katznelson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  95     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  366-72     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Bile Acids and Salts / analysis
Body Fluids / analysis
Cholecystokinin / diagnostic use
Diarrhea, Infantile / complications
Dietary Fats / metabolism*
Escherichia coli Infections / complications*
Feces / analysis
Gastroenteritis / complications*
Intestinal Absorption
Lipid Metabolism
Lipids / analysis
Malabsorption Syndromes / etiology*
Salmonella Infections / complications*
Salmonella typhimurium
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dietary Fats; 0/Lipids; 0/Micelles; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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