Document Detail

Disturbed flow-enhanced endothelial turnover in atherosclerosis.
MedLine Citation:
PMID:  20211434     Owner:  NLM     Status:  MEDLINE    
Endothelial dysfunction/death is an initial event for the development of atherosclerosis occurring in the areas of arteries where blood flow is disturbed. Recent data indicated that rapid turnover of endothelial cells in atherosclerosis-prone areas is followed by endothelial repair. The mechanisms of endothelial death/proliferation in these areas related to altered blood flow involve different signal pathways, for example, endoplasmic reticulum stress-X-box binding protein 1-caspase for apoptosis and vascular endothelial growth factor receptor-histone deacetylase 3-Akt for the survival. The present review aims to update the progress in endothelial turnover in response to disturbed flow and to discuss the underlining mechanisms in the development of atherosclerosis.
Qingbo Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  19     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2010-03-09     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Inc. All rights reserved.
Cardiovascular Division, King's College London BHF Center, London, United Kingdom.
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MeSH Terms
Atherosclerosis / metabolism,  pathology*,  physiopathology
Cell Proliferation*
Endothelium, Vascular / metabolism,  pathology*,  physiopathology
Regional Blood Flow
Signal Transduction
Stress, Mechanical
Grant Support
//British Heart Foundation

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