Document Detail

Disturbances of the microcirculation in acute pancreatitis.
MedLine Citation:
PMID:  16607683     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Severe acute pancreatitis is characterized by pancreatic necrosis, resulting in local and systemic inflammation. Pancreatitis affects both the systemic and pancreatic vasculature. This review focuses on the underlying processes involved in the changes of microvascular anatomy following acute pancreatitis. METHODS: A Medline/PubMed search (January 1966 to December 2005) with manual cross-referencing was conducted. All relevant articles investigating the pancreatic microcirculatory anatomy and the effect of pancreatitis on the microcirculation were included. RESULTS: The pancreas is susceptible to ischaemic insult, which can exacerbate acute pancreatitis. There is also increasing evidence of pancreatic and systemic microvascular disturbances in the pathogenesis of pancreatitis, including vasoconstriction, shunting, inadequate perfusion, and increased blood viscosity and coagulation. These processes may be caused or exacerbated by ischaemia-reperfusion injury and the development of oxygen-derived free radicals. CONCLUSION: Acute pancreatitis impairs the pancreatic and systemic microcirculation, which is a key pathological process in the development of severe necrotizing disease.
C M Cuthbertson; C Christophi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of surgery     Volume:  93     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-05-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  518-30     Citation Subset:  AIM; IM    
Department of Surgery, University of Melbourne, Austin Hospital, Lance Townsend Building Level 8, Heidelberg, Victoria 3084, Australia.
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MeSH Terms
Acute Disease
Blood Coagulation Disorders / etiology
Endothelium, Vascular / physiology
Microcirculation / physiology
Pancreas / blood supply*
Pancreatitis / complications,  physiopathology*
Reperfusion Injury / etiology,  physiopathology
Vascular Diseases / etiology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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