Document Detail

Disturbances in lipid metabolism in diabetic pregnancy - Are these the cause of the problem?
MedLine Citation:
PMID:  20832733     Owner:  NLM     Status:  MEDLINE    
The most common neonatal complication of gestational diabetes (GDM) is macrosomia. During early pregnancy an accumulation of maternal fat depots occurs followed by increased adipose tissue lipolysis and subsequent hyperlipidaemia, which mainly corresponds to increased triglycerides (TG) in all circulating lipoproteins. In GDM women, the enhanced insulin resistance and decreased oestrogens are responsible for the reported wide range of dyslipidaemic conditions. In GDM, decreased proportion of long chain polyunsaturated fatty acids in fetus plasma could result from decreased supply, impaired placental transfer or even altered intrauterine metabolism. A positive correlation between maternal TG and neonatal body weight or fat mass has been found in GDM. Augmented oxidative stress and altered adipokines have also been found, with an adverse outcome even in normoglycaemic conditions. Thus, although additional studies are required, overall these findings indicate that altered maternal lipid metabolism rather than hyperglycaemia constitutes a risk for macrosomia in GDM.
Emilio Herrera; Henar Ortega-Senovilla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  24     ISSN:  1878-1594     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-07     Revised Date:  2012-11-07    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  515-25     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ltd. All rights reserved.
Universidad San Pablo CEU, Boadilla del Monte, Madrid, Spain.
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MeSH Terms
Adipokines / physiology
Adipose Tissue / growth & development
Birth Weight
Diabetes, Gestational / metabolism*
Fetal Macrosomia / etiology*
Fetus / metabolism
Hyperlipidemias / etiology
Hypertriglyceridemia / etiology
Infant, Newborn
Lipid Metabolism*
Placenta / metabolism
Pregnancy in Diabetics / metabolism*
Triglycerides / metabolism
Reg. No./Substance:
0/Adipokines; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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