| Disturbances in lipid metabolism in diabetic pregnancy - Are these the cause of the problem? | |
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MedLine Citation:
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PMID: 20832733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The most common neonatal complication of gestational diabetes (GDM) is macrosomia. During early pregnancy an accumulation of maternal fat depots occurs followed by increased adipose tissue lipolysis and subsequent hyperlipidaemia, which mainly corresponds to increased triglycerides (TG) in all circulating lipoproteins. In GDM women, the enhanced insulin resistance and decreased oestrogens are responsible for the reported wide range of dyslipidaemic conditions. In GDM, decreased proportion of long chain polyunsaturated fatty acids in fetus plasma could result from decreased supply, impaired placental transfer or even altered intrauterine metabolism. A positive correlation between maternal TG and neonatal body weight or fat mass has been found in GDM. Augmented oxidative stress and altered adipokines have also been found, with an adverse outcome even in normoglycaemic conditions. Thus, although additional studies are required, overall these findings indicate that altered maternal lipid metabolism rather than hyperglycaemia constitutes a risk for macrosomia in GDM. |
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Authors:
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Emilio Herrera; Henar Ortega-Senovilla |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Best practice & research. Clinical endocrinology & metabolism Volume: 24 ISSN: 1532-1908 ISO Abbreviation: Best Pract. Res. Clin. Endocrinol. Metab. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120682 Medline TA: Best Pract Res Clin Endocrinol Metab Country: Netherlands |
Other Details:
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Languages: eng Pagination: 515-25 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Universidad San Pablo CEU, Boadilla del Monte, Madrid, Spain. eherrera@ceu.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipokines
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physiology Adipose Tissue / growth & development Birth Weight Diabetes, Gestational / metabolism* Female Fetal Macrosomia / etiology* Fetus / metabolism Humans Hyperlipidemias / etiology Hypertriglyceridemia / etiology Infant, Newborn Lipid Metabolism* Placenta / metabolism Pregnancy Pregnancy in Diabetics / metabolism* Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adipokines; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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