Document Detail

Disturbances of acid-base balance and bone disease in end-stage renal disease.
MedLine Citation:
PMID:  10923356     Owner:  NLM     Status:  MEDLINE    
Bone disease in patients with chronic renal failure (CRF) is thought to be the consequence primarily of the interplay of several factors, including the serum levels of parathyroid hormone (PTH), vitamin D, calcium, and phosphorus, and exposure to bone toxins such as aluminum or amyloid. Recently the metabolic acidosis noted with CRF has been implicated as an additional factor contributing to the genesis of bone disease. Although metabolic acidosis might be the dominant factor in the cause of bone disease in some instances, more commonly this acid-base disturbance interacts with other factors contributing to the development of bone disease. The following article summarizes the data in support of an important role for metabolic acidosis in the genesis of bone disease in patients with CRF and presents our recommendations for treatment of uremic acidosis to prevent or treat the bone disease.
J A Kraut
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Seminars in dialysis     Volume:  13     ISSN:  0894-0959     ISO Abbreviation:  Semin Dial     Publication Date:    2000 Jul-Aug
Date Detail:
Created Date:  2000-12-13     Completed Date:  2000-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911629     Medline TA:  Semin Dial     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Division of Nephrology, VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA.
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MeSH Terms
Acid-Base Imbalance / diagnosis,  etiology*,  therapy
Bone Diseases, Metabolic / diagnosis,  etiology*,  prevention & control
Kidney Failure, Chronic / complications*,  diagnosis,  therapy
Risk Assessment

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