| Disturbance of response to acute thermal pain in naturally occurring cholecystokinin-a receptor gene knockout Otsuka Long-Evans Tokushima Fatty (OLETF) rats. | |
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MedLine Citation:
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PMID: 16891771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Otsuka Long-Evans Tokushima Fatty (OLETF) rats lack cholecystokinin-A receptor (CCK-AR) because of a genetic abnormality. We observed that body temperature homeostasis in response to changes in ambient temperature was deteriorated in OLETF rats, while the functions of the signal outputs from the hypothalamus to effectors were not impaired. Deteriorated homeostasis was also seen in CCK-AR deficient (-/-) mice. In the present study, we examined whether the sensory pathway involved in transmitting signals about temperature from the skin to the brain was impaired in OLETF rats. To elucidate the involvement of CCK-AR function, we conducted the same experiment in CCK-AR(-/-) mice. Responses to thermal pain were assessed using the Hargreaves' plantar test apparatus. Shortening of withdrawal latency was observed in OLETF rats compared to control rats, indicating thermal hyperalgesia. Behavioral responses following paw withdrawal were disturbed in OLETF rats. The 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid contents in the hippocampus and frontal cortex of OLETF rats were significantly higher than in those of the controls. CCK-AR(-/-) mice did not show any differences from wild-type mice. In conclusion, OLETF rats showed thermal hyperalgesia and disturbed responses to thermal pain, and an alteration of 5-HT function might have a role in this disturbance. |
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Authors:
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Kyoko Miyasaka; Shigeki Nomoto; Minoru Ohta; Setsuko Kanai; Takao Kaneko; Shoichi Tahara; Akihiro Funakoshi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-08-05 |
Journal Detail:
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Title: Journal of pharmacological sciences Volume: 101 ISSN: 1347-8613 ISO Abbreviation: J. Pharmacol. Sci. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-10-03 Revised Date: 2008-05-05 |
Medline Journal Info:
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Nlm Unique ID: 101167001 Medline TA: J Pharmacol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 280-5 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan. miyasaka@tmig.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Cerebral Cortex / metabolism Corpus Striatum / metabolism Dopamine / metabolism Hippocampus / metabolism Hydroxyindoleacetic Acid / metabolism Hyperalgesia / etiology, physiopathology* Infrared Rays / adverse effects Male Mice Mice, Knockout Norepinephrine / metabolism Pain Measurement / instrumentation, methods Pain Threshold Rats Rats, Inbred OLETF Reaction Time Receptor, Cholecystokinin A / deficiency, genetics, physiology* Serotonin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Cholecystokinin A; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid |
| Comments/Corrections | |
Comment In:
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J Pharmacol Sci. 2007 Dec;105(4):372
[PMID:
18094525
]
J Pharmacol Sci. 2007 Dec;105(4):373 [PMID: 18094526 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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