Document Detail

Disturbance of myocardial energy liberation in experimental charcoal embolism of canine pulmonary artery.
MedLine Citation:
PMID:  1031959     Owner:  NLM     Status:  MEDLINE    
Experimental charcoal embolism of the pulmonary artery was produced in dogs. Changes in hemodynamics, electrophysiology, and cardiac energy liberation were observed. The effects of histaminic and antihistaminic drugs on these changes were also studied. After two infusions of charcoal suspension, acute right ventricular overloading was recognized hemodynamically and electrophysiologically. Mitochondria isolated from both ventricles exhibited uncoupling of oxidative phosphorylation polarographically. These changes were enhanced with histamine injection and reduced with diphenhydramine injection. Histamine was seen to have some uncoupling effects on the heart mitochondria and a slight effect on cardiac dynamics. It is concluded that oxidative phosphorylation of the heart mitochondria was uncoupled in the acute stage of experimental pulmonary embolism, and that histamine might emphasize this change directly or indirectly or both, that is, directly affecting the myocardial cell metabolism, and indirectly aggravating myocardial hypoxia through pulmonary vasoconstrictive action.
T Tanimoto; T Ishiyama; Y Morita; Y Hatanaka; T Ueno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent advances in studies on cardiac structure and metabolism     Volume:  11     ISSN:  0363-5872     ISO Abbreviation:  Recent Adv Stud Cardiac Struct Metab     Publication Date:    1976 May 26-29
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0325677     Medline TA:  Recent Adv Stud Cardiac Struct Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  605-8     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Disease Models, Animal
Embolism / physiopathology
Energy Metabolism*
Heart / physiopathology*
Heart Rate
Mitochondria, Heart / metabolism*
Oxidative Phosphorylation
Oxygen Consumption
Pulmonary Artery / physiology
Pulmonary Heart Disease / physiopathology*
Reg. No./Substance:
16291-96-6/Charcoal; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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