| Distributions of current and new first-trimester Down syndrome screening markers in twin pregnancies. | |
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MedLine Citation:
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PMID: 20306463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To study the distributions of pregnancy-associated plasma protein A (PAPP-A), the free beta subunit of human chorion gonadotrophin (fbeta-hCG), A Disintegrin and Metalloprotease 12 (ADAM12) and Placental Protein 13 (PP13) in first trimester twin pregnancies. METHODS: Serum marker concentrations were measured in monochorionic and dichorionic twin pregnancies and singleton controls to study differences in multiples of the gestation-specific normal medians (MoMs). RESULTS: Median PAPP-A and fbeta-hCG MoMs were 2.03 and 1.87 for monochorionic twins (n = 116) and 2.18 and 1.89 for dichorionic twins (n = 650). Furthermore, ADAM12 and PP13 MoMs were 1.66 and 1.56 for monochorionic twins (n = 51) and 1.64 and 1.53 for dichorionic twins (n = 249). No statistically significant differences between monochorionic and dichorionic twin pregnancies were found. Correlations between markers in these pregnancies did not differ from singletons. CONCLUSION: For first-trimester screening, different parameters for monochorionic and dichorionic twin pregnancies is not necessary. Furthermore, if ADAM12 and PP13 will be adopted as screening markers, the presented median MoM values, standard deviations and correlation coefficients for twin pregnancies may contribute to a proper twin risk estimation. |
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Authors:
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M P H Koster; E J Wortelboer; Ph Stoutenbeek; G H A Visser; P C J I Schielen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 30 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 413-7 Citation Subset: IM |
Affiliation:
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Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment, Bilthoven, the Netherlands. wendy.koster@rivm.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ADAM Proteins
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blood Adult Biological Markers / blood Case-Control Studies Chorionic Gonadotropin, beta Subunit, Human / blood Diseases in Twins / blood* Down Syndrome / blood*, diagnosis Female Galectins / blood Gestational Age Humans Membrane Proteins / blood Pregnancy Pregnancy Proteins / blood Pregnancy Trimester, First / blood* Pregnancy-Associated Plasma Protein-A / metabolism Prenatal Diagnosis / methods* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Galectins; 0/LGALS13 protein, human; 0/Membrane Proteins; 0/Pregnancy Proteins; EC 3.4.24.-/ADAM 12 protein; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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