Document Detail

Distributions of PCNA and Cas-3 in rat uterus during early pregnancy.
MedLine Citation:
PMID:  20529819     Owner:  NLM     Status:  MEDLINE    
The aim of present study was to determine the distributions of proliferating cell nuclear agent (PCNA) and Cas-pase-3 (Cas-3) and their possible roles in implantation and decidualization during early pregnancy at immunohistochemical level. The tissue samples from pregnant animals between gestational days 1-5 were incubated by PCNA and Cas-3 antibodies and the obtained results were evaluated quantitatively. It was observed that PCNA immunoreactivity in uterine luminal epithelium and glandular epithelium reduced as from day 2 of gestation and disappeared as from day 4 of gestation. PCNA staining intensity in stromal cells and myometrium increased gradually with progressing gestation. While Cas-3 immunoreactivity was strongly detected in luminal and glandular epithelium throughout the whole gestational period, its reactivity markedly increased as from day 3 of gestation. In conclusion, it may suggest that the blastocyst implantation induces the uterine luminal epithelial cell death and stromal cell proliferation around the embryo in the uterus.
Hakan Oner; Jale Oner; Ramazan Demir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  48     ISSN:  1897-5631     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  71-7     Citation Subset:  IM    
Department of Histology and Embryology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Turkey.
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MeSH Terms
Caspase 3 / metabolism*
Epithelium / enzymology
Myometrium / cytology,  enzymology
Proliferating Cell Nuclear Antigen / metabolism*
Uterus / cytology,  enzymology*
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen; EC 3.4.22.-/Caspase 3

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