Document Detail


Distributional analyses for children's inhalation risk assessments.
MedLine Citation:
PMID:  18097947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discussion here is divided into three parts. First there is a generic introduction to variability and uncertainty and a discussion of some underappreciated features of these concepts that have nontrivial implications for structuring risk analyses. Next are some suggestions for a way forward to build a better quantitative understanding of relevant variability and uncertainty. The process involves building databases of putative analogous cases to represent the concerns that are now reflected in the various point-estimate "uncertainty factors" or "adjustment factors" in the formulas used to derive current reference doses and reference concentrations (RfDs and RfCs). The use of such databases is illustrated with some limited selections from our own databases where some preliminary comparisons between child and adult population variability in activity and respiratory response parameters are possible. A final section reflects on the current evolution of practice in estimating variability in risk assessments.
Authors:
Dale Hattis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  71     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-21     Completed Date:  2008-01-10     Revised Date:  2008-02-28    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  218-26     Citation Subset:  IM    
Affiliation:
George Perkins Marsh Institute, Clark University, Worcester, Massachusetts 01610,USA. dhattis@aol.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Child, Preschool
Databases, Factual*
Dose-Response Relationship, Drug
Female
Humans
Inhalation Exposure*
Male
Models, Statistical*
Risk Assessment / methods*
Uncertainty*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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