Document Detail

Distribution of vascular resistance and compliance in a dog lung lobe.
MedLine Citation:
PMID:  7118629     Owner:  NLM     Status:  MEDLINE    
We have modeled the left lower dog lung lobe as three serial compartments, each containing resistance (R) and compliance (C). The intracompartmental arrangement of R and C was chosen to permit their evaluation from pressure data obtained following occlusion of the venous outflow. We found that two mathematically distinct models permitted evaluation of the distribution of R and C. The models were complementary in that when used together the R and C of the three compartments could be determined. The central compartment had 46% of the lobar vascular resistance and 75% of the lobar vascular compliance under control conditions. We found that serotonin and histamine, which increased the resistance proximal and distal to the central compartment, respectively, did not increase the central resistance. Therefore, we conclude that the central compartment includes the capillary bed. The equilibrium pressure (Pd), obtained when arterial inflow and venous outflow were simultaneously occluded, was in close agreement with the average preocclusion pressure of the central compartment, indicating that Pd is close to the pulmonary microvascular pressure.
J H Linehan; C A Dawson; D A Rickaby
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  53     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  158-68     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Histamine / pharmacology
Microcirculation / drug effects
Models, Cardiovascular*
Pulmonary Circulation* / drug effects
Serotonin / pharmacology
Vascular Resistance* / drug effects
Grant Support
Reg. No./Substance:
50-67-9/Serotonin; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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