Document Detail


Distribution of tandem repeat polymorphism within minisatellite MS621 (D5S110).
MedLine Citation:
PMID:  8835094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The minisatellite MS621 (D5S110) is a highly polymorphic tandem repeat locus which maps to the distal region of human chromosome 5p. Major repeat unit variants at D5S110 differ not by base substitutions but by differences in the repetition of an 11 bp sequence motif found within each repeat. The two major classes of repeat unit thus contain two ('dimeric' = D-type) or three ('trimeric' = T-type) copies of this short motif. Mapping the distribution of these D- and T-type repeat units within alleles has allowed the analysis of the structural basis of allelic variation and of one de novo mutation. In contrast to previous studies of some other highly polymorphic minisatellites, this analysis provided no clear evidence for polarized variability at D5S110.
Authors:
J A Armour; M Crosier; A J Jeffreys
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of human genetics     Volume:  60     ISSN:  0003-4800     ISO Abbreviation:  Ann. Hum. Genet.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0416661     Medline TA:  Ann Hum Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-20     Citation Subset:  IM    
Affiliation:
Department of Genetics, University of Leicester, UK. joa@le.ac.uk
Data Bank Information
Bank Name/Acc. No.:
GENBANK/X79896;  X79897
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 5
DNA Primers
DNA, Satellite*
Genomic Imprinting
Germ-Line Mutation
Heterozygote
Humans
Minisatellite Repeats*
Molecular Sequence Data
Polymorphism, Genetic*
Primates
Sequence Alignment
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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