Document Detail


Distribution and synthesis of type VII collagen in oral squamous cell carcinoma.
MedLine Citation:
PMID:  9385579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of the basement membrane anchoring fibril component type VII collagen was studied in oral squamous cell carcinoma by using in situ hybridization and immunohistochemical methods. The expression of type VII collagen in oral normal mucosa, lichen planus and epithelial dysplasias was also investigated. In squamous cell carcinomas, the signals for type VII collagen mRNA were located exclusively in malignant peripheral cells in tumour islands and in fibroblast-like cells among the stromal tissue. In normal buccal mucosa, type VII collagen mRNA expression was located in basal epithelial cells. In oral lichen planus and epithelial dysplasias, the signals for type VII collagen mRNA were also located in basal keratinocytes; however, the signal was especially strong in some epithelial cells. In oral squamous cell carcinomas, the linear immunohistochemical staining pattern of type VII collagen was noted surrounding partly squamous epithelial tumour cell islands, and a large number of tumour cells showed a cytoplasmic staining reaction using the type VII collagen antibody. Some fibroblast-like stromal cells also showed a positive immunostaining reaction. In conclusion, the results of this study indicate that a high synthesis level, but an impaired distribution of type VII collagen, are highly characteristic of squamous epithelial tumour cells.
Authors:
T Kainulainen; R Grenman; A Oikarinen; D S Greenspan; T Salo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  26     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-23     Completed Date:  1997-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  414-8     Citation Subset:  D; IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, University of Oulu, Finland.
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MeSH Terms
Descriptor/Qualifier:
Basement Membrane / metabolism,  pathology
Carcinoma, Squamous Cell / metabolism,  pathology*
Cell Adhesion Molecules / analysis,  biosynthesis
Collagen / analysis*,  biosynthesis,  genetics
Cytoplasm / metabolism,  ultrastructure
Epithelial Cells / cytology,  metabolism
Epithelium / metabolism,  pathology
Fibroblasts / metabolism,  pathology
Humans
Immunohistochemistry
In Situ Hybridization
Keratinocytes / metabolism,  pathology
Lichen Planus, Oral / metabolism,  pathology
Mouth Mucosa / cytology,  metabolism,  pathology
Mouth Neoplasms / metabolism,  pathology*
RNA, Messenger / analysis
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/RNA, Messenger; 0/kalinin; 9007-34-5/Collagen

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